Description

Caspase-2 CAS NO 182372-14-1 is a high-purity, synthetic peptide inhibitor specifically designed to target the caspase-2 enzyme, a key initiator caspase in the apoptotic signaling pathway. This compound is critical for researchers and developers in life sciences who require precise tools to study programmed cell death mechanisms and validate drug targets. It is an essential reagent for pharmaceutical R&D, academic research in cell biology, and the development of novel therapeutic agents for cancer and neurodegenerative diseases.

Application

• Biochemical Research: Used as a selective inhibitor to elucidate the specific role of caspase-2 in intrinsic apoptosis pathways.
• Drug Discovery & Validation: Serves as a critical reference standard and tool compound for screening and validating new caspase-2 targeted therapeutics.
• Cell Biology Studies: Enables controlled experiments to investigate caspase-2-mediated cellular responses to stress, DNA damage, and metabolic changes.
• Pharmaceutical Development: Employed in assay development and potency testing for candidate drugs aimed at modulating apoptosis.
• Neuroscience Research: Applied in models studying neuronal cell death, relevant to conditions like Alzheimer's and Parkinson's disease.
• Oncology Research: Utilized to understand tumor cell resistance and sensitivity to chemotherapeutic agents that trigger apoptosis.

Basic Information

Product Name	Caspase-2 Inhibitor
CAS No.	182372-14-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Z-VDVAD-FMK; Caspase-2 Inhibitor Z-VDVAD-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK; (Benzyloxycarbonyl)-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; Caspase 2 Selective Inhibitor; Apoptosis Inhibitor IV; Caspase-2 Peptide Inhibitor
EINECS	Contact for details

Quality Control

Our Caspase-2 inhibitor is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, assay results, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.