Description

(3-Fluoro-4-Hydroxyphenyl)Boronic Acid is a high-purity boronic acid derivative featuring both a fluorine substituent and a phenolic hydroxyl group on the aromatic ring. This bifunctional structure makes it a versatile and valuable building block in modern synthetic chemistry, particularly for cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require precise molecular construction for active pharmaceutical ingredients (APIs) and functional organic compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in pharmaceuticals and agrochemicals.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Ligand Synthesis for Catalysis: Used to create sophisticated boronic acid-based ligands for transition metal catalysts, enhancing reaction selectivity and efficiency.
• Functional Material Development: Employed in the synthesis of organic electronic materials, sensors, and metal-organic frameworks (MOFs) due to its ability to introduce both fluorine and boronic acid functionalities.
• Bioconjugation and Probe Chemistry: Utilized in the design of chemical probes and bioconjugation agents, leveraging the boronic acid group's affinity for diols.
• Agrochemical Research: Acts as a building block for developing new herbicides, fungicides, and plant growth regulators with improved properties.

Basic Information

Product Name	(3-Fluoro-4-Hydroxyphenyl)Boronic Acid
CAS No.	182344-14-5
Molecular Formula	C6H6BFO3
Molecular Weight	155.92 g/mol
Synonyms	3-Fluoro-4-hydroxybenzeneboronic acid; (3-Fluoro-4-hydroxy)phenylboronic acid; 4-Borono-2-fluorophenol; 2-Fluoro-4-boronophenol; B-(3-Fluoro-4-hydroxyphenyl)boronic acid; 3-Fluoro-4-hydroxyphenyl-Boronic Acid; 182344-14-5; 3-Fluoro-4-hydroxybenzeneboronic acid pinacol ester (common protected form)
EINECS	Contact for details

Quality Control

Our (3-Fluoro-4-Hydroxyphenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider using a desiccator or storing under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.