Description

4-(Bromomethyl)-2-Methoxybenzonitrile is a versatile brominated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a methoxy-substituted benzonitrile core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzyl or phenethylamine motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the benzonitrile moiety is a common structural feature.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of advanced polymers and liquid crystals.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Scale-Up: A fundamental starting material for contract research organizations (CROs) and CDMOs performing custom synthesis for clients.

Basic Information

Product Name	4-(Bromomethyl)-2-Methoxybenzonitrile
CAS No.	182287-68-9
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	2-Methoxy-4-(bromomethyl)benzonitrile; 4-Bromomethyl-2-methoxybenzonitrile; 2-Methoxy-4-(bromomethyl)phenyl cyanide; p-(Bromomethyl)-o-methoxybenzonitrile; 4-Bromo-2-cyanobenzyl methyl ether (incorrect but common misnomer); (4-Bromo-2-methoxyphenyl)acetonitrile derivative; Benzonitrile, 4-(bromomethyl)-2-methoxy-
EINECS	Contact for details

Quality Control

Every batch of 4-(Bromomethyl)-2-Methoxybenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) including purity (HPLC/GC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.