Description

4-(Bromomethyl)-3-Iodobenzonitrile is a versatile bifunctional aromatic building block containing both bromomethyl and iodo substituents ortho to a nitrile group. This unique combination of reactive halides makes it a critical intermediate for constructing complex molecular architectures through sequential cross-coupling and functional group transformations. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical sectors for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen diversity for creating diverse compound libraries.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where the benzonitrile core and halogen handles are advantageous.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Negishi) where the iodo group reacts selectively before the bromomethyl group, allowing for sequential functionalization.
• Derivatization Studies: Used in chemical biology for tagging and probe synthesis due to its reactive sites which can be further modified.

Basic Information

Product Name	4-(Bromomethyl)-3-Iodobenzonitrile
CAS No.	182287-63-4
Molecular Formula	C8H5BrIN
Molecular Weight	321.94 g/mol
Synonyms	3-Iodo-4-(bromomethyl)benzonitrile; 4-Bromomethyl-3-iodobenzonitrile; Benzonitrile, 4-(bromomethyl)-3-iodo-; 3-Iodo-4-bromomethylbenzonitrile; 4-(Bromomethyl)-3-iodobenzene carbonitrile; 182287-63-4; AI3-52075; CTK8C7265
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-3-Iodobenzonitrile is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.