Description

Bromoacetamido-Peg2 -Boc-Amine is a bifunctional PEG-based linker featuring a bromoacetamide group for thiol-specific conjugation and a Boc-protected amine for further chemical elaboration. This compound matters as a critical building block for creating stable, site-specific bioconjugates and functionalized materials with controlled spacing and solubility. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced polymer therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Development: Used as a heterobifunctional crosslinker to attach cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Peptide and Protein Modification: Enables site-specific labeling, PEGylation, or functionalization of thiol-containing biomolecules to enhance stability or add probes.
• Surface Functionalization: A key reagent for modifying gold nanoparticles, biosensor chips, or other surfaces to create bioactive interfaces for assays.
• Polymer Chemistry: Serves as a monomer or chain-transfer agent in the synthesis of functional, biocompatible polymers with pendant amine groups.
• Prodrug Synthesis: Facilitates the creation of cleavable linker systems in prodrug architectures designed for targeted release.
• Diagnostic Reagent Preparation: Employed in the conjugation of enzymes, fluorophores, or other detection molecules to antibodies or oligonucleotides for immunoassays.

Basic Information

Product Name	Bromoacetamido-Peg2 -Boc-Amine
CAS No.	182244-33-3
Molecular Formula	C₁₆H₃₁BrN₂O₆
Molecular Weight	427.33 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-amine, 14-[(1,1-dimethylethoxy)carbonyl]-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl bromoacetate; Boc-NH-PEG2-Bromoacetamide; t-Butyl (13-oxo-3,6,9-trioxa-12-azatetradec-1-yl) carbamate bromoacetate; Boc-Amino-PEG2-Bromoacetamide; Bromoacetyl-PEG2-Boc-amine; N-Boc-3,6-dioxa-8-aminooctyl bromoacetamide; 1-Boc-amino-3,6-dioxaoctyl-8-bromoacetamide
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg2 -Boc-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure compliance with research and cGMP-grade material standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.