Description

1-(Trimethylsilyl)-3,4-Difluorobenzene is a high-purity organosilicon intermediate featuring a difluorinated aromatic ring, prized for its role in introducing both silicon and fluorine functionalities into advanced molecular architectures. This compound is critical for synthesizing complex materials and active pharmaceutical ingredients (APIs) where precise structural modification is required. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for applications demanding high reactivity and purity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorinated compounds are advantageous.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the silicon and fluorine groups can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer & Resin Modification: Employed to introduce silyl and fluoro groups into polymer backbones, modifying characteristics such as thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: Acts as a versatile reagent in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems common in many advanced materials.
• Protecting Group Chemistry: The trimethylsilyl group can function as a protecting group for hydroxyl or other sensitive functionalities in multi-step synthetic pathways.

Basic Information

Product Name	1-(Trimethylsilyl)-3,4-Difluorobenzene
CAS No.	182193-04-0
Molecular Formula	C9H12F2Si
Molecular Weight	186.28 g/mol
Synonyms	3,4-Difluoro(trimethylsilyl)benzene; (3,4-Difluorophenyl)trimethylsilane; Trimethyl(3,4-difluorophenyl)silane; Benzene, 1-(trimethylsilyl)-3,4-difluoro-; 3,4-Difluorophenyltrimethylsilane; TMS-3,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3,4-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical properties are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.