Description

N,N''-[Dithiobis(o-Phenylenecarbonyl)]Bis-L-Isoleucine is a specialized chiral organic compound featuring a disulfide bridge and two L-isoleucine moieties, making it a valuable building block in advanced synthesis. This compound matters for its role in creating complex molecular architectures, particularly in the development of peptide mimetics and constrained bioactive molecules. It is needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug discovery and ligand design.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel peptide-based therapeutics and enzyme inhibitors.
• Bioconjugation Reagent: Utilized for creating stable, reducible disulfide linkages in antibody-drug conjugates (ADCs) and protein labeling.
• Chemical Biology Probe: Acts as a scaffold for developing activity-based probes to study protease and other enzyme functions.
• Material Science: Employed in the synthesis of functionalized polymers and smart materials requiring responsive disulfide bonds.
• Asymmetric Catalysis: Used as a precursor for chiral ligands or organocatalysts in stereoselective synthesis.
• Academic & Industrial Research: A critical reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	N,N''-[Dithiobis(o-Phenylenecarbonyl)]Bis-L-Isoleucine
CAS No.	182149-25-3
Molecular Formula	C26H32N2O4S2
Molecular Weight	500.67 g/mol
Synonyms	Bis-L-Isoleucine N,N''-[dithiobis(2,1-phenylene)]bisamide; L-Isoleucine, N,N'-[dithiobis(1,2-phenylene-1-carbonyl)]bis-; N,N'-(Dithiodi-1,2-phenylene)bis[2-amino-3-methylpentanamide]; Disulfide-linked bis(L-isoleucine o-carboxanilide); o,o'-Dithiobis(benzoic acid) bis(L-isoleucine amide); Bis(isoleucine) disulfide anilide derivative; [Disulfanediylbis(2,1-phenylene)]bis(azanediyl)bis(3-methyl-1-oxopentan-2-yl) (IUPAC-style)
EINECS	Contact for details

Quality Control

Our N,N''-[Dithiobis(o-Phenylenecarbonyl)]Bis-L-Isoleucine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, LC-MS) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L,L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.