Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Acetamidopropanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for the controlled assembly of complex peptides and peptidomimetics in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the biotechnology and pharmaceutical industries for drug discovery, API development, and the production of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected asparagine derivative for the sequential construction of peptide chains on resin supports.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based Active Pharmaceutical Ingredients (APIs) and therapeutic candidates.
• Peptidomimetic Design: Incorporates the acetamido side chain functionality into synthetic peptide analogs to enhance stability, bioavailability, or biological activity.
• Bioconjugation: Serves as a specialized linker or modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive peptide leads.
• Academic & Industrial Research: A fundamental reagent for studying protein structure-function relationships, enzyme substrates, and receptor ligands.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Acetamidopropanoic Acid
CAS No.	181952-29-4
Molecular Formula	C20H20N2O5
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-Asn(Ac)-OH; Fmoc-N-acetyl-L-asparagine; N-α-Fmoc-N-β-acetyl-L-asparagine; Nα-Fmoc-Nβ-acetyl-L-asparagine; (2S)-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-acetamidopropanoic acid; Fmoc-L-Asn(Ac)-OH; Fmoc-Asn(Ac)-OH; N-α-(9-Fluorenylmethyloxycarbonyl)-N-β-acetyl-L-asparagine
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Acetamidopropanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.