Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-3-Nitro- D-Tyrosine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the precise incorporation of modified tyrosine residues. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated synthesis of custom peptides containing nitro-tyrosine modifications.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates targeting various diseases, where tyrosine nitration can be studied for its biological effects.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity tags for proteomics and biochemical assay development.
• Academic & Industrial R&D: Employed in studies of post-translational modifications, oxidative stress pathways, and signal transduction mechanisms.
• Production of Reference Standards: Used to synthesize high-purity standards for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-3-Nitro- D-Tyrosine
CAS No.	181952-16-9
Molecular Formula	C26H22N2O7
Molecular Weight	474.47 g/mol
Synonyms	Fmoc-3-Nitro-D-Tyrosine; Fmoc-D-Tyr(3-NO2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-nitro-D-tyrosine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-nitro-4-hydroxyphenyl)propanoic acid; Fmoc-D-3-Nitrotyrosine; Fmoc-D-Tyr(NO2)-OH; Fmoc-3-Nitro-L-Tyrosine (D-isomer); Fmoc-D-Tyrosine(3-NO2)
EINECS	Contact for details

Quality Control

Our n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-3-Nitro- D-Tyrosine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.