Description

5-Bromo-2-(difluoromethoxy)-1,3-difluorobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents on a difluorobenzene core, makes it a critical intermediate for introducing specific fluorine-containing motifs into target molecules. This compound is primarily utilized by research institutions and industrial R&D teams in the pharmaceutical and agrochemical sectors for developing novel active ingredients, where its precise reactivity and fluorine content are invaluable.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and metabolic stability in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored compounds and proprietary intermediates.

Basic Information

Product Name	5-Bromo-2-(difluoromethoxy)-1,3-difluorobenzene
CAS No.	181806-67-7
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)-2,6-difluorobenzene; Benzene, 5-bromo-2-(difluoromethoxy)-1,3-difluoro-; 2,6-Difluoro-4-bromoanisole, difluoro-; 4-Bromo-2,6-difluorophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(difluoromethoxy)-1,3-difluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and stringent regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.