Description

1-Hydroxy Valdecoxib is a key pharmaceutical intermediate and a major metabolite of the COX-2 inhibitor valdecoxib. This compound is of significant importance for research and development in the field of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily utilized by pharmaceutical manufacturers and research institutions for analytical reference standards, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the pharmacokinetics, metabolism, and safety profile of valdecoxib.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a high-purity building block in the synthesis and process development of COX-2 inhibitor drugs.
• Bioanalytical Applications: Employed in the calibration of LC-MS/MS and HPLC systems for the precise quantification of valdecoxib and its metabolites in biological matrices.
• Impurity Profiling: Essential for identifying and characterizing related substances in valdecoxib bulk drug substances and finished dosage forms to meet ICH guidelines.

Basic Information

Product Name	1-Hydroxy Valdecoxib
CAS No.	181695-81-8
Molecular Formula	C16H14N2O4S
Molecular Weight	330.36 g/mol
Synonyms	4-[5-Methyl-3-phenyl-4-isoxazolyl]benzenesulfonamide, 1-Hydroxy Metabolite; Valdecoxib Hydroxy Metabolite; SC 66902; Parecoxib Impurity; Valdecoxib Related Compound A; 1-Hydroxyvaldecoxib; 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide 1-oxide
EINECS	Contact for details

Quality Control

Our 1-Hydroxy Valdecoxib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for identification, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure compliance with research and pharmaceutical industry standards. Custom synthesis and purification to meet specific pharmacopeial or internal specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.