Description

(2E)-5-(tert-Butyloxycarbonylamino)-5-Methylhex-2-Enoic Acid is a high-purity, protected amino acid derivative featuring a Boc-protected amine and a carboxylic acid functional group. This compound is a critical chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of peptide-based therapeutics and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based drugs and APIs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid building block.
• Protease Inhibitor Development: Serves as a precursor in the research and production of enzyme inhibitors.
• Chemical Biology Research: Employed in the study of protein-protein interactions and biochemical pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs for bespoke chemical synthesis projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and organic synthesis studies.

Basic Information

Product Name	(2E)-5-(tert-Butyloxycarbonylamino)-5-Methylhex-2-Enoic Acid
CAS No.	181646-42-4
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-5-methyl-(2E)-2-hexenoic acid; (E)-5-((tert-Butoxycarbonyl)amino)-5-methylhex-2-enoic acid; Boc-5-methyl-D,L-norleucine derivative; 5-Methyl-5-(Boc-amino)-2E-hexenoic Acid; Protected 5-Amino-5-methyl-2-hexenoic Acid; (2E)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-hexenoic acid; Boc-Amino Acid Derivative 181646-42-4
EINECS	Contact for details

Quality Control

Our (2E)-5-(tert-Butyloxycarbonylamino)-5-Methylhex-2-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.