Description

D-Aspartic Acid, 3-Fluoro-, Diethyl Ester, Hydrochloride, Erythro- (9Ci) is a high-purity, fluorinated derivative of aspartic acid, serving as a critical chiral building block and synthetic intermediate. This compound is engineered to introduce fluorine atoms and specific stereochemistry into target molecules, a key strategy for modulating their biological activity, metabolic stability, and physicochemical properties. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science who require precise, high-quality intermediates for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, metabolic diseases, and oncology.
• Peptidomimetics & Bioactive Peptide Synthesis: Used to incorporate fluorinated amino acid analogs into peptides to enhance their stability against enzymatic degradation and improve membrane permeability.
• Agrochemical Research: Serves as a building block for developing new-generation herbicides, fungicides, and plant growth regulators where the fluorine atom can enhance bioactivity and environmental persistence.
• Chemical Biology & Proteomics: Employed as a tool compound or labeled analog in mechanistic studies and probe development to investigate enzyme function and protein-protein interactions.
• Material Science Precursor: Potential use in the synthesis of specialized polymers, dendrimers, or liquid crystals where fluorinated amino acid derivatives can impart unique thermal and surface properties.
• Academic & Process Chemistry: A valuable reagent for methodological development in asymmetric synthesis, catalysis, and studying fluorine-specific chemical transformations in academic and industrial R&D settings.

Basic Information

Product Name	D-Aspartic Acid, 3-Fluoro-, Diethyl Ester, Hydrochloride, Erythro- (9Ci)
CAS No.	181309-85-3
Molecular Formula	C8H15FNO4 · HCl
Molecular Weight	251.67 g/mol (Free base: 208.21 g/mol)
Synonyms	(2R,3S)-3-Fluoro-2-aminobutanedioic acid 1,4-diethyl ester hydrochloride; D-erythro-3-Fluoroaspartic acid diethyl ester hydrochloride; Diethyl (2R,3S)-3-fluoroaspartate hydrochloride; (2R,3S)-Diethyl 3-fluoroaspartate hydrochloride; 3-Fluoro-D-aspartic acid diethyl ester HCl; Erythro-DL-3-fluoroaspartic acid diethyl ester hydrochloride (isomer specified); 9CI Reference Compound 181309-85-3; Fluorinated D-Aspartic acid ester salt.
EINECS	Contact for details

Quality Control

Every batch of D-Aspartic Acid, 3-Fluoro-, Diethyl Ester, Hydrochloride, Erythro- (9Ci) is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, chiral HPLC, GC, NMR, and MS to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Erythro-D isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.