Description

(R)-3-(tert-Butoxycarbonylamino)-2-Phenylpropanoic Acid is a high-purity chiral building block and protected amino acid derivative. This compound is essential for the synthesis of complex, biologically active molecules where stereochemical integrity is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide drugs and enzyme inhibitors.
• Peptide Synthesis: Serves as a protected (Boc) amino acid component in solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Used as a starting material or chiral auxiliary in asymmetric catalytic reactions to introduce the (R)-phenylalanine moiety.
• Bioconjugation & Labeling: The carboxylic acid group allows for coupling reactions, useful in creating labeled probes or drug conjugates.
• Chemical Biology Research: Employed in the design and synthesis of substrate analogs, inhibitors, and molecular tools for studying biological pathways.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) producing custom fine chemicals for clients.

Basic Information

Product Name	(R)-3-(tert-Butoxycarbonylamino)-2-Phenylpropanoic Acid
CAS No.	181140-88-5
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	(R)-Boc-Phenylalanine; (R)-N-Boc-Phenylalanine; (R)-2-Phenyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; (R)-N-(tert-Butoxycarbonyl)-Phenylalanine; Boc-D-Phenylalanine (incorrect but common alias); (R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-phenylpropanoic acid; (R)-N-Boc-Phe-OH; (R)-Boc-Phe-OH
EINECS	Contact for details

Quality Control

Our (R)-3-(tert-Butoxycarbonylamino)-2-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.