Description

(Ile5,Trp23,Tyr36)-Pth-Related Protein (1-36) (Human, Mouse, Rat) CAS NO 181057-31-8 is a synthetic peptide fragment derived from the parathyroid hormone-related protein (PTHrP) sequence, engineered with specific amino acid substitutions to enhance stability and biological activity. This compound is a critical research tool for studying calcium metabolism, bone biology, and the role of PTHrP in various physiological and pathological processes, including cancer. It is primarily utilized by academic, pharmaceutical, and biotechnology researchers focused on endocrinology, oncology, and metabolic disease.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating PTHrP signaling pathways, receptor binding, and downstream effects on calcium and phosphate homeostasis.
• Drug Discovery & Development: Serves as a key pharmacological tool for screening and validating potential therapeutics targeting PTH/PTHrP receptors for conditions like osteoporosis and hypercalcemia of malignancy.
• In Vitro & In Vivo Assays: Employed in cell-based assays (e.g., cAMP stimulation) and animal model studies to elucidate the protein's role in skeletal development, lactation, and tumor progression.
• Antibody Production & Characterization: Acts as a specific immunogen or antigen for generating and testing antibodies against distinct epitopes of the PTHrP molecule.
• Mechanistic Studies: Facilitates research into post-translational modifications, protein-protein interactions, and the structural determinants of PTHrP bioactivity.

Basic Information

Product Name	(Ile5,Trp23,Tyr36)-Pth-Related Protein (1-36) (Human, Mouse, Rat)
CAS No.	181057-31-8
Molecular Formula	C194H301N55O55S
Molecular Weight	4295.9 g/mol
Synonyms	PTHrP (1-36) (Ile5,Trp23,Tyr36); [Ile5,Trp23,Tyr36]-PTHrP(1-36); Parathyroid Hormone-Related Protein (1-36) amide, modified; PTHrP (1-36) analog; hPTHrP(1-36) (Ile5,Trp23,Tyr36); PTHrP 1-36 amide (human, mouse, rat); PTHLH (1-36) peptide; Hypercalcemic factor peptide fragment
EINECS	Contact for details

Quality Control

Every batch of our (Ile5,Trp23,Tyr36)-PTHrP (1-36) peptide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing HPLC purity, MS confirmation, amino acid analysis, and peptide content are available upon request, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere or in a vacuum-sealed container after opening. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.