Description

Dota-Biotin-Sarcosine CAS NO 180978-54-5 is a specialized biotin derivative and a key intermediate in the synthesis of advanced radiopharmaceuticals and diagnostic agents. This compound is engineered to provide a stable, high-affinity chelating platform for technetium-99m and other radioisotopes, enabling precise targeting in molecular imaging. It is primarily required by research institutions and pharmaceutical manufacturers developing novel PET and SPECT imaging probes for oncology and neurology applications.

Application

• Radiopharmaceutical Precursor: A critical building block for synthesizing biotinylated chelators used in targeted diagnostic imaging agents.
• Molecular Imaging Probes: Used in the development of novel probes for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Avidin-Biotin Technology: Serves as a linker molecule in avidin-biotin complex (ABC) systems for diagnostic assays and targeted drug delivery research.
• Cancer Research: Enables the study of tumor targeting and biodistribution when conjugated to tumor-specific vectors like peptides or antibodies.
• Contrast Agent Development: Investigated for use in creating advanced contrast agents for multimodal imaging applications.
• Bioconjugation Chemistry: Provides a functional handle for site-specific conjugation of biomolecules due to its biotin and carboxylic acid groups.

Basic Information

Product Name	Dota-Biotin-Sarcosine
CAS No.	180978-54-5
Molecular Formula	C26H43N7O10S
Molecular Weight	645.73 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, mono[N-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide]-, (4R)-; DOTA-Biotin; DOTA-Biotin Sarcosine; Biotin-DOTA; DOTA-Biotinamide; DOTA-Biotin conjugate; Biotinyl-DOTA; DOTA-Biotin complex
EINECS	Contact for details

Quality Control

Our Dota-Biotin-Sarcosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support development projects requiring material that aligns with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.