Description

Cyclohexanecarbonitrile, 5-Methyl-2-(1-Methylethyl)-, (1S,2S,5R)- (9Ci) is a high-purity, stereochemically defined nitrile derivative of menthol. This compound serves as a critical chiral intermediate and building block in advanced organic synthesis, offering precise molecular architecture for complex chemical transformations. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries seeking to introduce the (1S,2S,5R)-menthyl framework into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in flavor, fragrance, and therapeutic agent synthesis.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to induce desired optical activity in final products.
• Flavor & Fragrance Chemistry: Serves as a precursor for synthesizing high-value aroma chemicals and flavorants with minty or cooling characteristics.
• Agrochemical Research: Building block for creating novel, optically active crop protection agents and pesticides.
• Material Science: Intermediate in the synthesis of specialty polymers and liquid crystals where the rigid cyclohexane core is beneficial.
• Academic & Industrial R&D: Reference standard and reagent for methodological development in organic and medicinal chemistry laboratories.

Basic Information

Product Name	Cyclohexanecarbonitrile, 5-Methyl-2-(1-Methylethyl)-, (1S,2S,5R)- (9Ci)
CAS No.	180978-26-1
Molecular Formula	C11H19N
Molecular Weight	165.28 g/mol
Synonyms	(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexanecarbonitrile; (-)-Menthyl cyanide; (1S,2S,5R)-Menthane carbonitrile; L-Menthone cyanohydrin derivative; (1S,2S,5R)-2-Isopropyl-5-methylcyclohexanecarbonitrile; (-)-Menthonitrile
EINECS	Contact for details

Quality Control

Our production of Cyclohexanecarbonitrile, 5-Methyl-2-(1-Methylethyl)-, (1S,2S,5R)- (9Ci) adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by chiral HPLC to confirm stereochemical integrity and assayed for purity. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.