Description

3,3,3-Trifluoro-2,2-Dimethylpropionic Acid is a specialized fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group and a sterically hindered quaternary carbon, makes it a valuable precursor for introducing lipophilic and electron-withdrawing properties into target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated motifs to modulate potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated monomers and additives used in liquid crystal displays (LCDs) and specialty polymers with unique dielectric properties.
• Advanced Polymer Modification: Incorporation into polymer backbones to create materials with improved chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis & Catalysis: Valuable reagent for preparing ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Fluorinated Surfactant & Coating Precursor: Used to synthesize specialty surfactants and surface treatment agents with low surface energy for high-performance coatings.

Basic Information

Item	Detail
Product Name	3,3,3-Trifluoro-2,2-Dimethylpropionic Acid
CAS No.	180918-40-5
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	2,2-Dimethyl-3,3,3-trifluoropropionic Acid; 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid; TFPA; Trifluorodimethylpropionic Acid; α,α-Dimethyl-β,β,β-trifluoropropionic Acid; (Trifluoromethyl)dimethylacetic Acid; 3,3,3-Trifluoro-2,2-dimethylpropionic acid; 180918-40-5
EINECS	Contact for details

Quality Control

Our 3,3,3-Trifluoro-2,2-Dimethylpropionic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizers, and sources of ignition. Due to its acidic nature, ensure containers are made of compatible materials (e.g., fluoropolymer-lined).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.