Description

Candesartan N2-Glucuronide is a major, pharmacologically active metabolite of the angiotensin II receptor antagonist Candesartan. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK). It serves as a vital reference standard for analytical method development, bioanalytical studies, and regulatory compliance testing within the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Candesartan metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand the metabolic pathway, clearance, and exposure of Candesartan.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS or HPLC methods for clinical and pre-clinical trials.
• Impurity Profiling: Acts as a known impurity or degradation product for stability-indicating method development and quality control of Candesartan drug substances and products.
• Regulatory Submissions: Supports Investigational New Drug (IND) and New Drug Application (NDA) filings by providing definitive metabolite identification and characterization data.
• Academic & Contract Research: Used in universities and CROs for cardiovascular research and advanced analytical chemistry projects.

Basic Information

Product Name	Candesartan N2-Glucuronide
CAS No.	180603-76-3
Molecular Formula	C33H34N6O8
Molecular Weight	642.66 g/mol
Synonyms	Candesartan N2-Glucuronide; Candesartan Glucuronide; 2-[[(Cyclohexyloxy)carbonyl]amino]-α-[[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-propanoic acid β-D-Glucopyranosiduronic acid; (2-Ethoxy-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]benzofuran-7-yl)methyl β-D-Glucopyranosiduronic acid; Candesartan metabolite; TCV-116 metabolite; CV-11974 glucuronide
EINECS	Contact for details

Quality Control

Our Candesartan N2-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, LC-MS identification, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to guarantee traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.