Description

3-n-Fmoc-3-Phenylpropionic Acid is a key protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound matters for its role as a versatile building block, enabling the controlled introduction of modified phenylalanine residues into peptide chains. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial Fmoc-protected intermediate for the controlled assembly of complex peptides.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Serves as a building block for creating non-natural peptide analogs with enhanced stability or biological activity.
• Bioconjugation: The carboxylic acid functionality allows for coupling to other molecules, such as proteins, labels, or solid supports.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new lead compounds.
• Academic & Institutional Research: Used in biochemical and medicinal chemistry studies investigating protein-protein interactions and signaling pathways.

Basic Information

Product Name	3-n-Fmoc-3-Phenylpropionic Acid
CAS No.	180181-93-5
Molecular Formula	C24H20O4
Molecular Weight	372.42 g/mol
Synonyms	3-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoic Acid; Fmoc-3-amino-3-phenylpropionic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-phenylpropanoic Acid; 3-(Fmoc-amino)-3-phenylpropionic Acid; N-Fmoc-3-phenyl-β-alanine; Fmoc-APPA; (3R/S)-3-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-3-phenylpropanoic Acid
EINECS	Contact for details

Quality Control

Our 3-n-Fmoc-3-Phenylpropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0 - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.