Description

Minodronic Acid is a potent third-generation bisphosphonate compound, recognized for its high affinity for bone mineral hydroxyapatite. This property makes it a critical active pharmaceutical ingredient (API) for developing treatments targeting bone resorption disorders. It is primarily utilized by pharmaceutical manufacturers and research institutions in the life sciences sector. The compound is supplied to meet the stringent quality requirements of global regulatory standards for pharmaceutical development and production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for osteoporosis and Paget's disease of bone.
• Oncological Support: Development of adjunct therapies to manage skeletal-related events (SREs) such as hypercalcemia of malignancy and bone metastases.
• Preclinical & Clinical Research: Serves as a reference standard and key intermediate in pharmacological studies and new drug formulation research.
• Analytical Standard: Used in quality control laboratories for method development, validation, and assay calibration in pharmaceutical analysis.
• Chemical Synthesis: Acts as a key synthetic intermediate for creating novel bisphosphonate derivatives and prodrugs.

Basic Information

Product Name	Minodronic Acid
CAS No.	180064-38-4
Molecular Formula	C9H12N2O7P2
Molecular Weight	322.15 g/mol
Synonyms	Minodronic Acid Hydrate; YM-529; Minodronate; (1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid); Minodronic Acid Monohydrate; ONO-5920; Minodronate Monohydrate; [1-Hydroxy-1-(imidazo[1,2-a]pyridin-3-yl)methylidene]bisphosphonic acid
EINECS	Contact for details

Quality Control

Our Minodronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity specifications suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP, JP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5% (anhydrous basis)
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.