Description

2,2-Difluorothioacetamide is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethylthio moiety, enabling the introduction of sulfur and fluorine atoms into target molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for incorporating the SCF2H group into potential drug candidates, particularly in medicinal chemistry for protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides with enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for synthesizing fluorinated polymers or ligands with specific electronic properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution or cross-coupling reactions to construct complex, fluorinated heterocycles and other advanced structures.
• Chemical Biology Probe Development: Useful for creating activity-based probes or labeling reagents to study enzyme function and biological pathways.

Basic Information

Product Name	2,2-Difluorothioacetamide
CAS No.	180002-32-8
Molecular Formula	C2H3F2NS
Molecular Weight	111.11 g/mol
Synonyms	2,2-Difluoroethanethioamide; Difluorothioacetamide; Thioacetamide, 2,2-difluoro-; SCF2H-CONH2; 2,2-Difluoro-1-thioxoethan-1-amine
EINECS	Contact for details

Quality Control

Our 2,2-Difluorothioacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere after opening. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.