Description

5-Bromo-2-Fluorobenzonitrile is a high-purity, versatile aromatic nitrile building block essential for advanced organic synthesis. Its unique halogen-substituted structure makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, material science, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated benzonitrile core.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitrile group.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of the 5-bromo-2-fluorophenyl moiety into complex architectures.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and molecular recognition studies.

Basic Information

Product Name	5-Bromo-2-Fluorobenzonitrile
CAS No.	179897-89-3
Molecular Formula	C7H3BrFN
Molecular Weight	200.01 g/mol
Synonyms	2-Fluoro-5-bromobenzonitrile; 5-Bromo-2-fluorobenzene carbonitrile; 2-Fluoro-5-bromophenyl cyanide; 5-Bromo-2-fluorophenyl cyanide; Benzonitrile, 5-bromo-2-fluoro-; 179897-89-3; 5-Br-2-F-Bn
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥98.0%
Melting Point	65 - 69 °C
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.