Description

H-D-Ser(Tbu)-Otbu Hcl is a protected serine derivative, specifically the hydrochloride salt of the tert-butyl ether of O-tert-butyl-D-serine. This high-purity building block is critical for the synthesis of complex peptides and peptidomimetics, where precise stereochemistry and side-chain protection are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Research: Essential for academic and industrial research focused on creating novel peptide sequences with specific biological activities.
• Bioconjugation: Used in the preparation of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates for targeted therapies.
• Combinatorial Chemistry: Serves as a valuable monomer in libraries for high-throughput screening to identify new lead compounds.
• Proteomics & Biochemistry: Employed in the synthesis of substrate analogs, enzyme inhibitors, and labeled peptides for mechanistic studies.
• Material Science: Potential use in the development of specialized biomaterials and peptide-based polymers.

Basic Information

Product Name	H-D-Ser(Tbu)-Otbu Hcl
CAS No.	179559-35-4
Molecular Formula	C11H24ClNO3
Molecular Weight	253.77 g/mol
Synonyms	H-D-Ser(OtBu)-OtBu.HCl; D-Serine, O-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester, hydrochloride; (R)-2-((tert-Butoxy)methyl)-2-((tert-butoxycarbonyl)amino)acetic acid hydrochloride; Boc-D-Ser(OtBu)-OtBu HCl; N-[(tert-Butoxy)carbonyl]-O-(tert-butyl)-D-serine tert-butyl ester hydrochloride; D-Ser(OtBu)-OtBu hydrochloride; Fmoc-D-Ser(OtBu)-OtBu precursor
EINECS	Contact for details

Quality Control

Our H-D-Ser(Tbu)-Otbu Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.