Description

Amyloid β-Protein (33-42) is a specific peptide fragment derived from the amyloid precursor protein, representing a key sequence involved in β-sheet formation. This compound is of critical importance for researchers studying the molecular mechanisms of protein aggregation and neurotoxicity in Alzheimer's disease and related disorders. It is primarily needed by biotechnology, pharmaceutical R&D, and academic laboratories for use as a reference standard, in biochemical assays, and for the development of diagnostic tools and therapeutic agents.

Application

• Neuroscience Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid peptides.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid-beta aggregation.
• Diagnostic Development: Serves as a critical antigen or standard in the development and calibration of immunoassays (ELISA, Western Blot) for detecting amyloid-beta species.
• Biophysical Studies: Investigation of peptide-lipid membrane interactions and the formation of oligomeric or fibrillar structures using techniques like spectroscopy and electron microscopy.
• Antibody Production & Validation: Used as an immunogen to generate sequence-specific antibodies or to test antibody specificity.
• Cell Culture Models: Application in cellular models to induce and study amyloid-related cytotoxicity and pathological pathways.

Basic Information

Product Name	Amyloid β-Protein (33-42)
CAS No.	178949-81-0
Molecular Formula	C48H73N13O13
Molecular Weight	1032.2 g/mol
Synonyms	Aβ(33-42); Amyloid β-Protein (33-42); Amyloid Beta (33-42); β-Amyloid (33-42); Aβ33-42; Amyloid β-Peptide (33-42); H-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (33-42) is produced and analyzed under stringent conditions to ensure the highest standards of identity, purity, and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, molecular weight confirmation by mass spectrometry, and peptide content. We adhere to quality management principles suitable for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	1032.2 ± 1.0 Da
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, Acetic Acid; Sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.