Description

3-Bromo-1-(2,2,2-Trifluoroethyl)Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrrolidinone scaffold substituted with bromine and a trifluoroethyl group. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoroethyl group can impart favorable properties.
• Chemical Biology Probe Development: Serves as a versatile scaffold for constructing molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique fluorinated characteristics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	3-Bromo-1-(2,2,2-Trifluoroethyl)Pyrrolidin-2-One
CAS No.	178946-24-2
Molecular Formula	C6H7BrF3NO
Molecular Weight	246.03 g/mol
Synonyms	3-Bromo-1-(2,2,2-trifluoroethyl)-2-pyrrolidinone; 1-(2,2,2-Trifluoroethyl)-3-bromo-2-pyrrolidinone; 3-Bromo-1-(trifluoroethyl)pyrrolidin-2-one; 2-Pyrrolidinone, 3-bromo-1-(2,2,2-trifluoroethyl)-; 178946-24-2; 3-Bromo-1-(2,2,2-trifluoroethyl) pyrrolidinone
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-1-(2,2,2-Trifluoroethyl)Pyrrolidin-2-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.