Description

Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1R-Cis)- (9Ci) CAS NO 178899-56-4 is a high-purity, chiral cyclopropane derivative featuring both ethoxy and methoxy substituents alongside an ethynyl group, making it a valuable and versatile synthetic intermediate. Its stereochemically defined cis configuration is critical for applications requiring precise molecular geometry and enantiomeric purity. This compound is primarily sought after by research institutions and pharmaceutical development teams for use in advanced organic synthesis, particularly in the construction of complex molecules for drug discovery and material science.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used in the development of new generation pesticides and herbicides where the cyclopropane ring structure contributes to biological activity.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the research of specialty polymers and advanced organic materials with tailored properties.
• Ligand Synthesis: Employed in the creation of sophisticated chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & R&D: A crucial reagent for methodological studies in organic chemistry, including cycloaddition reactions and ring-opening polymerizations.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural products, flavors, and fragrances.

Basic Information

Product Name	Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1R-Cis)- (9Ci)
CAS No.	178899-56-4
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(1R,2S)-2-Ethoxy-1-ethynyl-1-methoxycyclopropane; (1R-cis)-2-Ethoxy-1-ethynyl-1-methoxycyclopropane; 1-Methoxy-1-ethynyl-2-ethoxycyclopropane, (1R-cis)-; 178899-56-4; (1R,2S)-1-Ethynyl-1-methoxy-2-ethoxycyclopropane; cis-2-Ethoxy-1-ethynyl-1-methoxycyclopropane
EINECS	Contact for details

Quality Control

Every batch of our Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1R-Cis)- (9Ci) is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, and chiral analysis to ensure high enantiomeric excess (ee) and chemical purity meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is between 2°C and 8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.