Description

Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1S-Trans)- (9Ci) is a specialized chiral cyclopropane derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring both ethynyl and alkoxy substituents on a strained three-membered ring, makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where its defined stereochemistry and functional group handles enable efficient synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the cyclopropane ring contributes to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored electronic or structural properties.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including cycloaddition reactions and ring-opening polymerizations.
• Fine Chemical Production: Acts as a building block for synthesizing complex flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1S-Trans)- (9Ci)
CAS No.	178751-93-4
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(1S,2S)-2-Ethoxy-1-ethynyl-1-methoxycyclopropane; (1S-trans)-2-Ethoxy-1-ethynyl-1-methoxycyclopropane; 1-Methoxy-2-ethoxy-1-ethynylcyclopropane, (1S-trans)-; trans-2-Ethoxy-1-ethynyl-1-methoxycyclopropane; Chiral Ethynyl Methoxy Ethoxy Cyclopropane; 1-Ethynyl-1-methoxy-2-ethoxycyclopropane; 178751-93-4; (1S,2S)-1-Ethynyl-1-methoxy-2-ethoxycyclopropane
EINECS	Contact for details

Quality Control

Our Cyclopropane, 2-Ethoxy-1-Ethynyl-1-Methoxy-, (1S-Trans)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and mass spectrometry to confirm identity, enantiomeric excess, and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is between 2°C and 8°C. This compound is easily oxidized; ensure containers are properly sealed to exclude moisture and air after each use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.