Description

2-Fluoro-3-(trifluoromethyl)phenylacetic acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical R&D teams and agrochemical manufacturers developing next-generation active ingredients, as well as by specialty chemical producers creating advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for CNS, anti-inflammatory, and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving thermal stability and optical properties.
• Polymer Chemistry: Incorporated as a monomer or modifier to produce specialty polymers with enhanced chemical resistance and unique surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new reactions involving fluorinated arenes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules for client projects.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)phenylacetic Acid
CAS No.	178748-05-5
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	[2-Fluoro-3-(trifluoromethyl)phenyl]acetic Acid; 2-Fluoro-α-(trifluoromethyl)benzeneacetic Acid; (2-Fluoro-3-trifluoromethylphenyl)acetic Acid; 2-Fluoro-3-(trifluoromethyl)benzenacetic Acid; α-Carboxy-2-fluoro-3-trifluoromethyltoluene; 2-Fluoro-3-trifluoromethylphenylacetic Acid; 178748-05-5; FTFMPAA
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)phenylacetic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.