Description

(R)-4-tert-Butyl-2-[(R)-2-(Bis(1-Phenyl)-Phosphino)Ferrocen-1-Yl]Oxazoline is a highly specialized chiral ferrocenyl phosphine-oxazoline ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for the efficient and cost-effective synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a key step in active pharmaceutical ingredient (API) synthesis.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions such as allylic alkylation, conjugate addition, and cross-coupling to construct chiral carbon frameworks.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral building blocks for cardiovascular, central nervous system (CNS), and oncological drugs with high optical purity.
• Agrochemical Active Ingredient Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Process Chemistry & Scale-Up: Provides robust and reproducible performance for transitioning asymmetric catalytic processes from laboratory to pilot and commercial scale.
• Academic & Industrial Research: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.

Basic Information

Product Name	(R)-4-tert-Butyl-2-[(R)-2-(Bis(1-Phenyl)-Phosphino)Ferrocen-1-Yl]Oxazoline
CAS No.	178557-28-3
Molecular Formula	C33H34FeNOP
Molecular Weight	547.46 g/mol
Synonyms	(R)-4-tert-Butyl-2-[(R)-2-(Diphenylphosphino)ferrocenyl]oxazoline; (R,R)-t-Bu-FerroPHOX; (R,R)-FerroPHOX; (R,R)-t-Bu-FerroPHOS-Oxazoline; (R,R)-4-tert-Butyl-2-[2-(Diphenylphosphino)ferrocenyl]-4,5-dihydrooxazole; Ferrocenyl Phosphine-Oxazoline Ligand; Josiphos-type Oxazoline Ligand; Chiral Ferrocene Ligand.
EINECS	Contact for details

Quality Control

Every batch of (R)-4-tert-Butyl-2-[(R)-2-(Bis(1-Phenyl)-Phosphino)Ferrocen-1-Yl]Oxazoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the ligand meets the high standards required for sensitive asymmetric catalysis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, chemical purity, and metal content.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.