Description

n-Fmoc-3-Hydroxy-L-Phenylalanine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of the tyrosine-like 3-hydroxyphenylalanine residue into peptide chains, enabling the research and development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on peptide-based drug discovery, proteomics, and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated or manual synthesis of complex peptides.
• Peptide Drug Discovery: Used in the research and development of therapeutic peptides targeting various diseases.
• Chemical Biology Probes: Incorporation into peptides for studying protein-protein interactions, enzyme activity, and cellular signaling pathways.
• Bioconjugation: Serves as a precursor for creating peptide-based conjugates for drug delivery or diagnostic applications.
• Academic & Industrial Research: Fundamental reagent for synthetic chemistry and biochemistry research in university and corporate laboratories.
• Production of Non-Natural Amino Acid Derivatives: Used as an intermediate for further chemical modification to create specialized amino acid analogs.

Basic Information

Product Name	n-Fmoc-3-Hydroxy-L-Phenylalanine
CAS No.	178432-48-9
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-3-hydroxy-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxy-L-phenylalanine; Fmoc-Tyr(3-OH)-OH; Fmoc-3-HO-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3-hydroxyphenyl)propanoic acid; N-Fmoc-3-hydroxy-L-phenylalanine; 3-Hydroxy-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Hydroxy-L-Phenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.