Description

3-(4-Propoxy-1-Piperidinyl)-1-Boc-Azetidine is a high-purity, advanced pharmaceutical intermediate featuring a piperidine-azetidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting the central nervous system and other disease areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those requiring complex nitrogen-containing heterocycles.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead compound optimization for new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the development and scale-up of active pharmaceutical ingredient (API) synthesis routes.
• Protease Inhibitor Scaffolds: The structural motif is relevant for the development of protease inhibitors, a major class of therapeutic agents.
• GPCR-Targeted Drug Discovery: The piperidine moiety makes it valuable for research into compounds targeting G-protein-coupled receptors (GPCRs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-(4-Propoxy-1-Piperidinyl)-1-Boc-Azetidine
CAS No.	178312-31-7
Molecular Formula	C16H30N2O3
Molecular Weight	298.42 g/mol
Synonyms	1-Boc-3-(4-propoxy-1-piperidinyl)azetidine; tert-Butyl 3-(4-propoxy-1-piperidinyl)azetidine-1-carboxylate; 3-(4-Propoxypiperidin-1-yl)-1-(tert-butoxycarbonyl)azetidine; 1-(tert-Butoxycarbonyl)-3-(4-propoxy-1-piperidinyl)azetidine; 3-(4-Propoxy-1-piperidinyl)azetidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-(4-propoxy-piperidin-1-yl)-azetidine; 3-(4-Propoxy-piperidin-1-yl)-azetidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-(4-Propoxy-1-Piperidinyl)-1-Boc-Azetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the results against our stringent internal specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.