Description

Piboserod Hydrochloride CAS NO 178273-87-5 is a selective 5-HT4 receptor antagonist, a high-purity active pharmaceutical ingredient (API) of significant interest in pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, which has been investigated for potential therapeutic applications in gastrointestinal and cardiovascular disorders. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in preclinical studies, formulation development, and analytical method validation.

Application

• Pharmaceutical R&D: Core material for preclinical pharmacological studies and investigative new drug (IND) applications.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development (HPLC, LC-MS).
• Formulation Development: Used in the development and testing of solid dosage forms (e.g., tablets, capsules) for clinical trials.
• Mechanistic Studies: Critical for in vitro and in vivo studies targeting the 5-HT4 receptor pathway.
• Impurity Synthesis: Starting material or intermediate for the synthesis of related compounds and potential degradants for impurity profiling.
• Biochemical Assays: Used as a specific ligand in receptor binding assays and other high-throughput screening platforms.

Basic Information

Product Name	Piboserod Hydrochloride
CAS No.	178273-87-5
Molecular Formula	C22H26FN3O2 • HCl
Molecular Weight	419.92 g/mol
Synonyms	SB-207266-A; SB 207266; SB207266; (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride; 1-Butyl-4-piperidinylmethyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-carboxylate hydrochloride; Piboserod HCl; 5-HT4 receptor antagonist SB-207266-A
EINECS	Contact for details

Quality Control

Our Piboserod Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and control of related substances and residual solvents, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.