Description

(S)-4-Acetyloxy-Mandelonitrile is a high-value, chiral synthetic intermediate of significant importance in asymmetric synthesis. Its core value proposition lies in its role as a versatile building block for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily needed by research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for cardiovascular and central nervous system drugs.
• Asymmetric Synthesis: Serves as a crucial building block for constructing complex molecules with high enantiomeric purity via nucleophilic addition or further functionalization.
• Agrochemical Research: Used in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Employed as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, and fragrances that require precise stereochemical control.
• Academic & Contract Research: Essential reagent for methodological studies in organic chemistry and process development within CROs (Contract Research Organizations).

Basic Information

Product Name	(S)-4-Acetyloxy-Mandelonitrile
CAS No.	178201-08-6
Molecular Formula	C11H9NO3
Molecular Weight	203.19 g/mol
Synonyms	(S)-4-Acetoxy-2-hydroxy-2-phenylacetonitrile; (S)-4-Acetoxymandelonitrile; (S)-α-Hydroxy-4-acetoxybenzeneacetonitrile; (S)-2-(4-Acetoxyphenyl)-2-hydroxyacetonitrile; (S)-O4-Acetyl Mandelonitrile; (S)-4-(Acetyloxy)mandelonitrile; (S)-4-Acetyloxy-α-hydroxybenzenecetonitrile; (S)-4-Acetoxybenzaldehyde cyanohydrin
EINECS	Contact for details

Quality Control

Our (S)-4-Acetyloxy-Mandelonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with high-purity standards for research and GMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.