Description

(S)-α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Formyl-5-(Hydroxymethyl)-1H-Pyrrole-1-Hexanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and functionalized pyrrole ring. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapies. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for its role in constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, high-value active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the design and development of peptide-like molecules for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the creation of enzyme inhibitors targeting specific disease pathways.
• Chiral Synthesis: Utilized in asymmetric synthesis due to its defined (S)-configuration, ensuring stereochemical purity in final products.
• Bioconjugation Chemistry: The formyl and hydroxymethyl groups enable site-specific conjugation for antibody-drug conjugates (ADCs) or diagnostic agents.
• Academic & Contract Research: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	(S)-α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Formyl-5-(Hydroxymethyl)-1H-Pyrrole-1-Hexanoic Acid
CAS No.	178180-79-5
Molecular Formula	C18H28N2O6
Molecular Weight	368.43 g/mol
Synonyms	(S)-2-Formyl-5-(hydroxymethyl)-1H-pyrrole-1-hexanoic acid α-[(tert-butoxycarbonyl)amino]; Boc-L-4-Fornyl-5-hydroxymethyl-norvaline aldehyde; (S)-α-[(tert-Butoxycarbonyl)amino]-2-formyl-5-(hydroxymethyl)-1H-pyrrole-1-hexanoic acid; (S)-Boc-4-Formyl-5-hydroxymethyl-norvalinal; 178180-79-5; Boc-4-Fmh-Nva-OH aldehyde; A protected formylpyrrole amino acid derivative
EINECS	Contact for details

Quality Control

Every batch of (S)-α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Formyl-5-(Hydroxymethyl)-1H-Pyrrole-1-Hexanoic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay, chiral purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the container to reach room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.