Description

L-Ascorbic Acid-2-13C CAS NO 178101-89-8 is a stable isotope-labeled analog of Vitamin C, where the carbon atom at the 2-position is replaced with the carbon-13 (13C) isotope. This compound is essential for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic kits and reference standards for mass spectrometry and NMR studies.

Application

• Isotope-Labeled Internal Standard for the accurate quantification of ascorbic acid and its metabolites in biological matrices using LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing in pharmacokinetic, pharmacodynamic, and nutritional studies to elucidate the absorption, distribution, and metabolism of Vitamin C.
• Stable Isotope Dilution Assay (SIDA) development for clinical diagnostics and food analysis to ensure high precision and accuracy.
• NMR Spectroscopy Studies as a 13C-enriched probe for structural analysis and dynamic studies of biochemical processes.
• Manufacturing of Certified Reference Materials (CRMs) for the calibration of analytical instruments and method validation in quality control labs.
• Biochemical Research investigating antioxidant mechanisms, collagen synthesis, and cellular redox states under controlled isotopic conditions.

Basic Information

Product Name	L-Ascorbic Acid-2-13C
CAS No.	178101-89-8
Molecular Formula	C513CH8O6
Molecular Weight	177.12 g/mol (for 13C1)
Synonyms	Vitamin C-2-13C; (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one-2-13C; 3-Oxo-L-gulofuranolactone-2-13C; L-Ascorbate-2-13C; Ascorbic Acid-2-13C; 13C1-L-Ascorbic Acid; L-Threo-hex-2-enono-1,4-lactone-2-13C; Isotopically Labeled Vitamin C
EINECS	Contact for details

Quality Control

Every batch of L-Ascorbic Acid-2-13C is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific analytical data. Our quality commitment ensures the material meets the stringent requirements for research and diagnostic applications, supporting reproducibility and reliability in your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, desiccants are recommended within the storage container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+20.5° to +21.5°
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.