Description

Nociceptin (1-13) Amide CAS NO 178064-02-3 is a synthetic peptide fragment of the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ), specifically the N-terminal 1-13 sequence amidated at the C-terminus. This compound is a critical research tool for investigating the N/OFQ peptide (NOP) receptor system, which plays a significant role in modulating pain, anxiety, and reward pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuropharmacology and central nervous system (CNS) drug discovery.

Application

• Neuroscience Research: As a reference standard and active ligand for studying the pharmacology and signaling of the NOP receptor.
• Pain Modulation Studies: Investigation of its effects on nociception and the development of novel non-opioid analgesic targets.
• Behavioral Pharmacology: Research into the role of the N/OFQ system in anxiety, depression, stress responses, and addiction.
• Receptor Binding Assays: Used in competitive binding experiments to characterize receptor affinity and selectivity.
• Biochemical Pathway Analysis: Elucidating downstream cellular effects following NOP receptor activation.
• Peptide Structure-Activity Relationship (SAR) Studies: Serving as a core structure for the design and synthesis of novel peptide analogs.

Basic Information

Product Name	Nociceptin (1-13) Amide
CAS No.	178064-02-3
Molecular Formula	C72H111N21O19
Molecular Weight	1547.8 g/mol
Synonyms	Nociceptin (1-13)-NH2; Orphanin FQ (1-13) amide; N/OFQ(1-13)-NH2; Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2; FGGFTGARKSARK-NH2; NOP receptor agonist (1-13) fragment
EINECS	Contact for details

Quality Control

Our Nociceptin (1-13) Amide is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity determination by HPLC, mass spectrometry (MS) for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.