Description

(R)-tert-Butyl 3-(Benzyloxy)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected pyrrolidine derivative essential for advanced organic synthesis. Its primary value lies in serving as a key intermediate for the development of novel pharmaceuticals, particularly in the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive molecules. This compound is critically needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Asymmetric Synthesis: Used as a chiral auxiliary or scaffold in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetics & Proline Derivatives: Serves as a protected precursor for the introduction of functionalized pyrrolidine rings, common motifs in peptidomimetic drug design.
• Agrochemical Research: Employed in the development of novel, enantiomerically pure pesticides and herbicides.
• Catalyst & Ligand Development: Acts as a starting material for the preparation of chiral ligands and organocatalysts used in homogeneous catalysis.
• Academic & Process R&D: Utilized in research institutions and kilo labs for route scouting, optimization, and scale-up studies for new chemical entities.

Basic Information

Product Name	(R)-tert-Butyl 3-(Benzyloxy)Pyrrolidine-1-Carboxylate
CAS No.	177947-67-0
Molecular Formula	C16H23NO3
Molecular Weight	277.36 g/mol
Synonyms	1-Boc-3-(benzyloxy)-(R)-pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-(benzyloxy)pyrrolidine; (R)-3-Benzyloxy-1-Boc-pyrrolidine; tert-Butyl (3R)-3-(phenylmethoxy)-1-pyrrolidinecarboxylate; (R)-N-Boc-3-benzyloxypyrrolidine; (R)-1-Boc-3-benzyloxypyrrolidine; (R)-tert-Butyl 3-benzyloxypyrrolidine-1-carboxylate; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-(phenylmethoxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(Benzyloxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with detailed specifications, ensuring traceability and compliance with your research or cGMP requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.