Description

Dota-(Tyr3)-Octreotate is a synthetic peptide derivative, a key intermediate in the development of targeted radiopharmaceuticals. Its primary value lies in its ability to chelate radionuclides, enabling precise diagnostic imaging and therapeutic applications in nuclear medicine. This compound is essential for pharmaceutical R&D teams and manufacturers specializing in oncology and neuroendocrine tumor treatments, where targeted drug delivery is critical.

Application

• Primary intermediate in the synthesis of Ga-68 DOTA-TATE and Lu-177 DOTA-TATE for targeted radionuclide therapy (TRT).
• Critical precursor for PET (Positron Emission Tomography) imaging agents used in the diagnosis and staging of neuroendocrine tumors.
• Research and development of novel theranostic pairs for personalized cancer treatment.
• Development of peptide receptor radionuclide therapy (PRRT) formulations.
• Conjugation studies for improving radiopharmaceutical stability and biodistribution.
• Reference standard in analytical method development and quality control for peptide-based APIs.

Basic Information

Product Name	Dota-(Tyr3)-Octreotate
CAS No.	177943-89-4
Molecular Formula	C₆₅H₉₀N₁₄O₁₉S₂
Molecular Weight	1435.6 g/mol
Synonyms	DOTA-TATE; DOTA-(Tyr3)-octreotate; DOTA0-Tyr3-Octreotate; DOTA-Tyr3-Octreotate; (DOTA)0-Tyr3-Octreotate; DOTA-Octreotate; DOTA-TOC; Ga-68 DOTA-TATE precursor; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-Tyr3-Octreotate
EINECS	Contact for details

Quality Control

Our Dota-(Tyr3)-Octreotate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.