Description

D-Leucine, 3-Hydroxy-, Methyl Ester (9Ci) is a chiral, non-proteinogenic amino acid derivative, specifically the methyl ester of 3-hydroxy-D-leucine. This compound is a valuable building block in organic synthesis and pharmaceutical research, offering a defined stereocenter for the construction of complex molecules. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for applications such as peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel therapeutic agents and peptide-based drugs.
• Peptidomimetics Research: Used to create and study peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions.
• Biochemical Research: Employed in enzymatic studies and as a standard in analytical method development.
• Agrochemical Development: A potential intermediate for creating chiral active ingredients in crop protection products.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals and advanced materials.

Basic Information

Product Name	D-Leucine, 3-Hydroxy-, Methyl Ester (9Ci)
CAS No.	177770-10-4
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	Methyl (2R)-2-amino-4-methyl-3-hydroxypentanoate; (R)-Methyl 2-amino-3-hydroxy-4-methylpentanoate; 3-Hydroxy-D-leucine methyl ester; D-3-Hydroxyleucine methyl ester; Methyl D-β-hydroxyleucinate; (2R)-2-Amino-3-hydroxy-4-methylpentanoic acid methyl ester; (R)-2-Amino-3-hydroxy-4-methylpentanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our D-Leucine, 3-Hydroxy-, Methyl Ester (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.