Description

tert-Butyl 2-(Iodomethyl)-1-Pyrrolidinecarboxylate is a versatile and high-value iodinated pyrrolidine derivative, primarily used as a key synthetic intermediate in advanced organic synthesis. Its core value lies in the reactive iodomethyl group, which facilitates critical carbon-carbon bond-forming reactions, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates, especially those containing pyrrolidine or proline-like scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the pyrrolidine ring is a common pharmacophore.
• Chemical Biology & Proteomics: Serves as a precursor for synthesizing molecular probes, enzyme inhibitors, and affinity labels due to its reactive halogen functionality.
• Material Science Research: Employed in the development of advanced organic materials and functional polymers.
• Asymmetric Synthesis: The chiral center makes it a valuable starting material for constructing enantiomerically pure compounds via further functionalization.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce complex substituents.

Basic Information

Product Name	tert-Butyl 2-(Iodomethyl)-1-Pyrrolidinecarboxylate
CAS No.	177750-73-1
Molecular Formula	C10H18INO2
Molecular Weight	311.16 g/mol
Synonyms	1-Boc-2-(iodomethyl)pyrrolidine; tert-Butyl 2-(iodomethyl)pyrrolidine-1-carboxylate; 2-(Iodomethyl)-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-(iodomethyl)pyrrolidine; N-Boc-2-(iodomethyl)pyrrolidine; Boc-2-(iodomethyl)pyrrolidine; (2R)-1-tert-Butyl 2-(iodomethyl)pyrrolidine-1,2-dicarboxylate (for chiral forms); 2-Iodomethyl-1-N-Boc-pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Iodomethyl)-1-Pyrrolidinecarboxylate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While produced to meet high-grade standards, specific certifications (e.g., for GMP use) can be discussed and tailored to project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to maximize shelf life. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.