Description

n-α-Benzyloxycarbonyl-n-α-Methyl-L-Norvaline is a protected, non-proteinogenic amino acid derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the controlled construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease-targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a methylated norvaline residue with a benzyloxycarbonyl (Cbz) protecting group.
• Biochemical Research: Serves as a standard or reagent in studies exploring enzyme-substrate interactions, structure-activity relationships (SAR), and metabolic pathways.
• Peptidomimetic Design: Integral for creating modified peptide backbones that enhance stability, bioavailability, and target specificity of potential drug molecules.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex organic molecules and specialized amino acid derivatives.

Basic Information

Product Name	n-α-Benzyloxycarbonyl-n-α-Methyl-L-Norvaline
CAS No.	177659-78-8
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	Nα-Cbz-Nα-Methyl-L-norvaline; Z-N-Me-L-Nva-OH; Cbz-N-Methyl-L-norvaline; (S)-2-((Benzyloxy)carbonyl)(methyl)amino)pentanoic acid; N-Carbobenzyloxy-N-methyl-L-norvaline; Nα-Methyl-Nα-(benzyloxycarbonyl)-L-norvaline; Benzyl N-methyl-L-norvalyl carbonate
EINECS	Contact for details

Quality Control

Our n-α-Benzyloxycarbonyl-n-α-Methyl-L-Norvaline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.