Description

4,5-Dimethoxy-2-Nitrobenzyl-8-Bromo-Cgmp is a specialized, high-purity caged compound used as a photolabile protecting group for cyclic guanosine monophosphate (cGMP). This compound matters because it enables precise, light-triggered release of biologically active cGMP, a critical second messenger, for advanced research in cellular signaling and physiology. It is essential for researchers and developers in pharmaceutical R&D, neurobiology, and cardiovascular studies who require temporal and spatial control over intracellular cGMP concentrations.

Application

• Photopharmacology Research: As a caged cGMP precursor for studying the real-time dynamics of cGMP-dependent pathways, such as those involving protein kinase G (PKG) and cyclic nucleotide-gated (CNG) ion channels.
• Neuroscience and Cell Signaling: For investigating the role of cGMP in neuronal plasticity, synaptic transmission, and visual phototransduction with millisecond precision using UV light flash photolysis.
• Cardiovascular Physiology Studies: To probe cGMP-mediated vasodilation, smooth muscle relaxation, and the mechanisms of drugs like nitroglycerin and sildenafil (Viagra).
• Biochemical Assay Development: As a key reagent in developing high-throughput screening assays for phosphodiesterase (PDE) inhibitors and guanylyl cyclase activators.
• Academic and Industrial R&D: A critical tool for basic research in universities and for drug discovery pipelines in biotechnology and pharmaceutical companies.

Basic Information

Product Name	4,5-Dimethoxy-2-Nitrobenzyl-8-Bromo-Cgmp
CAS No.	177592-89-1
Molecular Formula	C₁₉H₂₀BrN₆O₁₀P
Molecular Weight	627.28 g/mol
Synonyms	8-Br-cGMP, 4,5-dimethoxy-2-nitrobenzyl ester; 8-Bromo-cyclic GMP, 4,5-dimethoxy-2-nitrobenzyl ester; Caged 8-Bromo-cGMP; 8-Br-caged cGMP; DMNB-caged 8-Br-cGMP; 8-Bromo-cyclic guanosine monophosphate, α-(4,5-Dimethoxy-2-nitrophenyl)ethyl ester; 8-Bromo-1,2-O-(4,5-dimethoxy-2-nitrobenzyliden)-guanosine-3',5'-cyclic monophosphate; Photolabile 8-Bromo-cGMP precursor.
EINECS	Contact for details

Quality Control

Our 4,5-Dimethoxy-2-Nitrobenzyl-8-Bromo-Cgmp is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for sensitive life science research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature before opening to minimize condensation and moisture uptake. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.