Description

Cyclopropanecarboxylic Acid, 2-Fluoro-, Propyl Ester, (1R-Cis)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopropane derivative. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex bioactive molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemistry and fluorination to modulate the properties of target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the fluorinated cyclopropane moiety enhances biological activity and stability.
• Ligand and Catalyst Development: Employed in organometallic chemistry for the synthesis of chiral ligands and catalysts used in asymmetric synthesis.
• Material Science Research: Acts as a monomer or precursor for developing specialty polymers with unique fluorinated properties.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to introduce fluorine atoms and rigid cyclopropane rings into lead compounds.
• Process Chemistry: Serves as a high-value intermediate in the scale-up and optimization of synthetic routes for commercial drug production.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-, Propyl Ester, (1R-Cis)- (9Ci)
CAS No.	177564-61-3
Molecular Formula	C7H11FO2
Molecular Weight	146.16 g/mol
Synonyms	(1R,2S)-2-Fluorocyclopropanecarboxylic acid propyl ester; (1R-cis)-2-Fluorocyclopropanecarboxylic acid propyl ester; Propyl (1R,2S)-2-fluorocyclopropanecarboxylate; Propyl (1R-cis)-2-fluorocyclopropanecarboxylate; 2-Fluorocyclopropanecarboxylic acid propyl ester, (1R-cis)-; (1R,2S)-rel-2-Fluorocyclopropanecarboxylic Acid Propyl Ester; Fluorocyclopropane propyl ester
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-, Propyl Ester, (1R-Cis)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity and impurity profile analysis via HPLC/GC. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.