Description

4-Trifluoromethylsulfanyl-Biphenyl is a specialized fluorinated biphenyl derivative featuring a trifluoromethylthio (-SCF₃) functional group, a key structural motif in advanced organic synthesis. This compound is valued for its ability to impart unique electronic and steric properties, making it a critical building block for the development of novel materials and active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating high-performance molecules with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable -SCF₃ group into lead compounds.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the trifluoromethylthio moiety can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core building block in the synthesis of fluorinated organic semiconductors and liquid crystal molecules for electronic displays.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing nature of the -SCF₃ group.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal stability, chemical resistance, and surface properties.
• Chemical Research & Development: A versatile reagent for method development and exploring new reaction pathways in fluoroorganic chemistry.

Basic Information

Product Name	4-Trifluoromethylsulfanyl-Biphenyl
CAS No.	177551-63-2
Molecular Formula	C₁₃H₉F₃S
Molecular Weight	254.27 g/mol
Synonyms	[4-(Trifluoromethylthio)]biphenyl; 4-(Trifluoromethylthio)-1,1'-biphenyl; 4-(Trifluoromethylsulfanyl)biphenyl; 1,1'-Biphenyl, 4-(trifluoromethylthio)-; p-(Trifluoromethylthio)biphenyl; Biphenyl-4-yl trifluoromethyl sulfide; 4-(Trifluoromethylsulfanyl)-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylsulfanyl-Biphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.