Description

Leptin, Human CAS NO 177404-21-6 is a critical 16 kDa protein hormone primarily secreted by adipose tissue, playing a fundamental role in regulating energy balance, metabolism, and neuroendocrine function. Its primary commercial value lies in its essential use as a high-purity reference standard and active ingredient in advanced life science research and biopharmaceutical development. This product is indispensable for researchers and manufacturers in the fields of endocrinology, metabolic disease studies, obesity research, and the development of therapeutic peptides and diagnostic assays.

Application

• Biomedical Research & Drug Discovery: Serves as a key reference standard and reagent in studies investigating appetite regulation, energy homeostasis, and metabolic pathways.
• In Vitro Diagnostic (IVD) Development: Used as a calibrated antigen in the production of immunoassays (ELISA, RIA) and test kits for quantifying leptin levels in biological samples.
• Pharmaceutical R&D: Acts as an active pharmaceutical ingredient (API) or intermediate in the preclinical development of peptide-based therapies targeting leptin-related disorders.
• Cell Culture & Biochemistry: Employed in cell-based assays to study leptin receptor signaling, adipocyte function, and related cellular mechanisms.
• Academic & Clinical Studies: Essential for universities and hospitals conducting fundamental and translational research on obesity, diabetes, and reproductive endocrinology.
• Quality Control & Standardization: Used by manufacturers as a purity standard to benchmark in-house produced leptin or related recombinant proteins.

Basic Information

Product Name	Leptin, Human
CAS No.	177404-21-6
Molecular Formula	C861H1383N241O267S7
Molecular Weight	~16 kDa (Approx. 16000 g/mol)
Synonyms	Human Leptin; OB Protein; Obesity Protein; LEP; OBS; Leptin (Human); Recombinant Human Leptin; Leptin Hormone; Leptin, Recombinant Human; Adipocyte-specific Secretory Protein
EINECS	Contact for details

Quality Control

Our Leptin, Human is manufactured under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant quality guidelines to ensure product integrity and traceability. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into working portions upon first thaw to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Biological Activity	Determined by cell-based assay
Endotoxin Level	< 1.0 EU/μg
Moisture Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.