Description

(R)- -Allyl-Proline Hydrochloride CAS NO 177206-69-8 is a high-purity, non-natural amino acid derivative featuring a chiral proline core modified with an allyl group. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, particularly for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug candidates, especially those targeting enzymatic pathways.
• Protease Inhibitor Development: Serves as a core structural component in the research and synthesis of novel inhibitors for various proteases.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational restraint and specific stereochemistry into peptide backbones for enhanced stability and bioactivity.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the impact of the allyl-proline moiety on potency and selectivity.
• Process Chemistry & Scale-up: Provides a reliable, high-quality starting material for the optimization and commercial-scale manufacturing of APIs.
• Academic & Industrial Research: A valuable reagent for synthetic organic chemists in academia and industry exploring new methodologies and bioactive compounds.

Basic Information

Product Name	(R)- -Allyl-Proline Hydrochloride
CAS No.	177206-69-8
Molecular Formula	C8H13NO2 • HCl
Molecular Weight	191.65 (Free base) / 228.11 (Hydrochloride)
Synonyms	(R)-1-Allylproline hydrochloride; (R)-1-(2-Propenyl)-L-proline hydrochloride; (R)-1-Allyl-L-proline hydrochloride; (R)-1-Allylpyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 1-(2-propen-1-yl)-, hydrochloride (1:1), (2R)-; Allyl-Proline HCl (R-isomer); (2R)-1-(Prop-2-en-1-yl)pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)- -Allyl-Proline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D. Specifications are verified by methods including HPLC, chiral analysis, and NMR. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.