Description

3-Fluoro- L-Phenylalanine, Methyl Ester, Hydrochloride is a fluorinated amino acid derivative, specifically the methyl ester hydrochloride salt of L-phenylalanine fluorinated at the 3-position. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and biotechnology sectors for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and enzyme modulators.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated phenylalanine residues, altering peptide stability, bioavailability, and receptor binding.
• Medicinal Chemistry Research: Serves as a building block in structure-activity relationship (SAR) studies to investigate the effect of fluorine substitution on pharmacokinetic properties.
• Agrochemical Development: Potential intermediate in the synthesis of novel, fluorinated active ingredients for crop protection products.
• Biochemical Tool: Can be used in metabolic studies and as a probe to investigate biological systems where fluorinated amino acids are incorporated.
• Reference Standard: Sourced for use as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-Fluoro- L-Phenylalanine, Methyl Ester, Hydrochloride
CAS No.	176896-74-5
Molecular Formula	C₁₀H₁₃ClFNO₂
Molecular Weight	233.67 g/mol
Synonyms	L-Phenylalanine, 3-fluoro-, methyl ester, hydrochloride; Methyl (2S)-2-amino-3-(3-fluorophenyl)propanoate hydrochloride; (S)-Methyl 2-amino-3-(3-fluorophenyl)propanoate hydrochloride; 3-Fluoro-L-phenylalanine methyl ester HCl; 3-F-Phe-OMe·HCl; Fmoc-3-F-Phe-OH (related precursor); 3-Fluorophenylalanine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro- L-Phenylalanine, Methyl Ester, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and production applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.