Description

Hydroxy Ritonavir is a key pharmaceutical intermediate and a structural analog of the antiretroviral drug Ritonavir. This compound is of significant importance in the research and development of novel protease inhibitors and other therapeutic agents targeting viral infections. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and the development of new drug candidates for antiviral therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Ritonavir and its structural analogs.
• Antiviral Drug Research: Used in the research and development of novel protease inhibitors for HIV and other viral diseases.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the manufacturing process of final drug substances.
• Biochemical Research: Employed in biochemical assays and studies to understand enzyme inhibition mechanisms.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry Development: Integral to scaling up and optimizing synthetic routes in process chemistry.

Basic Information

Product Name	Hydroxy Ritonavir
CAS No.	176655-56-4
Molecular Formula	C37H48N6O5S2
Molecular Weight	720.94 g/mol
Synonyms	N-[(2S,3S,5S)-3-Hydroxy-1-(1,3-thiazol-5-ylmethyl)-5-[[(2S)-2-[[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl]amino]-4-phenylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamic acid ethyl ester; Hydroxyritonavir; Ritonavir Hydroxy Analog; Ritonavir Impurity; Ritonavir Related Compound; L-735,524 Hydroxy Derivative; 5-Thiazoleethanol, α-[[(1S,2S,4S)-4-[[(2S)-2-[[(2-isopropyl-4-thiazolyl)methyl](methyl)amino]-2-oxo-1-[(phenylmethyl)carbamoyl]ethyl]amino]-2-hydroxy-1-(phenylmethyl)pentyl]amino]-, ethyl ester, (αS)-
EINECS	Contact for details

Quality Control

Our Hydroxy Ritonavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis to ensure it meets stringent standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.