Description

Artemisinin-D3 is a deuterium-labeled isotopologue of the potent antimalarial sesquiterpene lactone, Artemisinin. This high-purity labeled compound is essential for advanced pharmacokinetic and metabolic studies, providing critical insights into drug absorption, distribution, metabolism, and excretion (ADME). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and analysis of artemisinin-based therapeutics.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of artemisinin and its derivatives in biological matrices.
• Drug Metabolism Studies (DMPK): Used in Absorption, Distribution, Metabolism, and Excretion (ADME) research to trace metabolic pathways and identify metabolites without interference from endogenous compounds.
• Pharmacokinetic (PK) Profiling: Enables precise tracking of drug concentration over time in plasma and tissues for robust pharmacokinetic modeling.
• Bioavailability and Bioequivalence Studies: Facilitates reliable comparative studies between different drug formulations.
• Stable Isotope Labeling in Medicinal Chemistry: Employed in the synthesis of deuterated drug candidates to potentially alter metabolic profiles and improve therapeutic properties.
• Quality Control & Method Development: Acts as a reference material in the development and validation of analytical methods within quality control laboratories.

Basic Information

Product Name	Artemisinin-D3
CAS No.	176652-07-6
Molecular Formula	C15H19D3O5
Molecular Weight	285.35 g/mol
Synonyms	Artemisinin (deuterated); Artemisinin-d3; (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one-d3; Qinghaosu-d3; Dihydroartemisinin-d3 precursor; Deuterated Artemisinin; Arteannuin-d3
EINECS	Contact for details

Quality Control

Our Artemisinin-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity verification, and HPLC for chemical purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic enrichment, and residual solvents, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.